Wine binaries(wine and winedbg actually) doesn't run after
	system reboot because they don't know where shared libraries
	installed. ELF binaries should be linked with -rpath to tell
	them the place of sharelibs that were installed to
	non-standard place. (A kind of PURE ELF system doesn't have
	ldconfig)

How-To-Repeat: 
(i) install wine
# cd /usr/ports/emulators/wine && make install
$ wine
<< It works here >>

(ii) then reboot or ldconfig to default paths
# shutdown -r now
or
# ldconfig /usr/lib/compat /usr/X11R6/lib /usr/local/lib
# ldconfig -r|grep wine
<< nothing found >>
# ldd /usr/local/bin/wine
/usr/local/bin/wine:
        libwine.so => not found (0x0)
        libncurses.so.5 => /usr/lib/libncurses.so.5 (0x28065000)
        libxpg4.so.3 => /usr/lib/libxpg4.so.3 (0x280a5000)
        libm.so.2 => /usr/lib/libm.so.2 (0x280a7000)
        libutil.so.3 => /usr/lib/libutil.so.3 (0x280c3000)
        libc.so.4 => /usr/lib/libc.so.4 (0x280cd000)
<< It no longer works >>

(iii) with patch below
# cd /usr/ports/emulators/wine && patch < THISMAIL && make install
# ldconfig /usr/lib/compat /usr/X11R6/lib /usr/local/lib
# ldconfig -r|grep wine
<< nothing found of cource >>
# ldd /usr/local/bin/wine
/usr/local/bin/wine:
        libwine.so => /usr/local/lib/wine/libwine.so (0x28065000)
        libncurses.so.5 => /usr/lib/libncurses.so.5 (0x282ad000)
        libxpg4.so.3 => /usr/lib/libxpg4.so.3 (0x282ed000)
        libm.so.2 => /usr/lib/libm.so.2 (0x282ef000)
        libutil.so.3 => /usr/lib/libutil.so.3 (0x2830b000)
        libc.so.4 => /usr/lib/libc.so.4 (0x28315000)
<< /usr/local/lib/wine is hardcoded to ELF binary >>