Index: Makefile
===================================================================
--- Makefile	(revision 506459)
+++ Makefile	(working copy)
@@ -17,7 +17,7 @@
 		rapidjson>=0:devel/rapidjson
 LIB_DEPENDS=	libboost_system.so:devel/boost-libs
 
-USES=		bison:build cmake eigen:3 python
+USES=		bison:build cmake compiler:c++11-lang eigen:3 python
 USE_GITHUB=	yes
 GH_TUPLE=	schrodinger:maeparser:1.0.0:maeparser/External/CoordGen/maeparser \
 		schrodinger:coordgenlibs:ede3191:coordgenlibs/External/CoordGen/coordgenlibs
@@ -24,7 +24,8 @@
 USE_LDCONFIG=	yes
 
 CMAKE_OFF=	RDK_INSTALL_INTREE RDK_USE_FLEXBISON \
-		RDK_INSTALL_STATIC_LIBS RDK_SWIG_STATIC RDK_PGSQL_STATIC
+		RDK_INSTALL_STATIC_LIBS RDK_SWIG_STATIC RDK_PGSQL_STATIC \
+		RDK_OPTIMIZE_NATIVE
 CMAKE_ARGS=	-DFREEBSD_DOCSDIR:PATH=${DOCSDIR} -DCATCH_DIR=${LOCALBASE}
 
 DATADIR=	${PREFIX}/share/RDKit