diff --git a/science/orthanc-mysql/Makefile b/science/orthanc-mysql/Makefile
index c63b5c716eb9..6b41ad68762e 100644
--- a/science/orthanc-mysql/Makefile
+++ b/science/orthanc-mysql/Makefile
@@ -1,7 +1,7 @@
 # Created by: maintainer.freebsd@xpoundit.com
 
 PORTNAME=	orthanc-mysql
-DISTVERSION=	4.0
+DISTVERSION=	4.3
 CATEGORIES=	science
 MASTER_SITES=	https://www.orthanc-server.com/downloads/get.php?path=/plugin-mysql/:main \
 		https://www.orthanc-server.com/downloads/get.php?path=/orthanc/:framework \
@@ -30,12 +30,14 @@ USES=		cmake localbase mysql:client python:build ssl
 USE_LDCONFIG=	yes
 
 WRKSRC=		${WRKDIR}/OrthancMySQL-${PORTVERSION}
-CMAKE_SOURCE_PATH=	${WRKSRC}/MySQL
-CMAKE_OFF=	DBUILD_UNIT_TESTS USE_SYSTEM_ORTHANC_SDK USE_SYSTEM_UUID
+
 CMAKE_ARGS=	-DORTHANC_FRAMEWORK_ROOT=${WRKSRC}/MySQL/ThirdPartyDownloads/Orthanc-1.9.3/OrthancFramework/Sources \
 		-DORTHANC_FRAMEWORK_SOURCE=path
-CXXFLAGS+=	-I${LOCALBASE}/include -DNDEBUG
+CMAKE_OFF=	DBUILD_UNIT_TESTS USE_SYSTEM_ORTHANC_SDK USE_SYSTEM_UUID
+CMAKE_SOURCE_PATH=	${WRKSRC}/MySQL
+
 CFLAGS+=	-DORTHANC_ENABLE_LOGGING_PLUGIN -DNDEBUG
+CXXFLAGS+=	-I${LOCALBASE}/include -DNDEBUG
 
 PLIST_SUB=	DISTVERSION=${DISTVERSION}
 
diff --git a/science/orthanc-mysql/distinfo b/science/orthanc-mysql/distinfo
index 23cc7032cd8b..f73c567cbf40 100644
--- a/science/orthanc-mysql/distinfo
+++ b/science/orthanc-mysql/distinfo
@@ -1,6 +1,6 @@
-TIMESTAMP = 1620905033
-SHA256 (orthanc/OrthancMySQL-4.0.tar.gz) = 9420b7d3293768778fc4f60cc7d72c0e15c1287bead98f6c3a9beddf6865a09a
-SIZE (orthanc/OrthancMySQL-4.0.tar.gz) = 318342
+TIMESTAMP = 1629969268
+SHA256 (orthanc/OrthancMySQL-4.3.tar.gz) = 7a22cbb482809bc1f6732e3e582cbbf4449e9205f297453ad4c7b7792956efba
+SIZE (orthanc/OrthancMySQL-4.3.tar.gz) = 321585
 SHA256 (orthanc/Orthanc-1.9.3.tar.gz) = 41cc35a3d15ecb0d7b834e8e28a740cc4ffa1f333c019a764228d60e96608960
 SIZE (orthanc/Orthanc-1.9.3.tar.gz) = 1818313
 SHA256 (orthanc/e2fsprogs-1.44.5.tar.gz) = 2e211fae27ef74d5af4a4e40b10b8df7f87c655933bd171aab4889bfc4e6d1cc