diff --git a/net-im/py-matrix-synapse/Makefile b/net-im/py-matrix-synapse/Makefile
index 341db243b9ae..156745e5399b 100644
--- a/net-im/py-matrix-synapse/Makefile
+++ b/net-im/py-matrix-synapse/Makefile
@@ -2,7 +2,7 @@
 
 PORTNAME=	matrix-synapse
 DISTVERSIONPREFIX=	v
-DISTVERSION=	1.48.0
+DISTVERSION=	1.49.0
 CATEGORIES=	net-im python
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
@@ -40,13 +40,14 @@ RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}jsonschema>=3.0.0:devel/py-jsonschema@${PY_F
 		${PYTHON_PKGNAMEPREFIX}Jinja2>=2.9:devel/py-Jinja2@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}bleach>=1.4.3:www/py-bleach@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}typing-extensions>=3.7.4:devel/py-typing-extensions@${PY_FLAVOR} \
-		${PYTHON_PKGNAMEPREFIX}ijson>=3.0:devel/py-ijson@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}ijson>=3.1:devel/py-ijson@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}pyjwt1>=1.7.0:www/py-pyjwt1@${PY_FLAVOR} \
 		${LOCALBASE}/share/certs/ca-root-nss.crt:security/ca_root_nss
 
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}virtualenv>=15.0:devel/py-virtualenv@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}tox>=2.3.1:devel/py-tox@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}lxml>0:devel/py-lxml@${PY_FLAVOR} \
+		${PYTHON_PKGNAMEPREFIX}mock>=4.0.0:devel/py-mock@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}parameterized>=0.7.0:devel/py-parameterized@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}authlib>=0.14.0:security/py-authlib@${PY_FLAVOR}
 
diff --git a/net-im/py-matrix-synapse/distinfo b/net-im/py-matrix-synapse/distinfo
index 27435918a7c5..e7cda09cbcfa 100644
--- a/net-im/py-matrix-synapse/distinfo
+++ b/net-im/py-matrix-synapse/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1638293209
-SHA256 (matrix-org-synapse-v1.48.0_GH0.tar.gz) = 182facc856f8d0c0d2d0dd4105fae4f851297167c0ee95c202a3aad9ed86c486
-SIZE (matrix-org-synapse-v1.48.0_GH0.tar.gz) = 7591198
+TIMESTAMP = 1639753379
+SHA256 (matrix-org-synapse-v1.49.0_GH0.tar.gz) = 3c1b73eb36ec3af00868707b929f9b9d1faae9ccc4022c2c46bdb025ef0ead8e
+SIZE (matrix-org-synapse-v1.49.0_GH0.tar.gz) = 7636737
diff --git a/net-im/py-matrix-synapse/files/patch-synapse_python__dependencies.py b/net-im/py-matrix-synapse/files/patch-synapse_python__dependencies.py
index 7f4fcfa8c06e..4b3041fc7432 100644
--- a/net-im/py-matrix-synapse/files/patch-synapse_python__dependencies.py
+++ b/net-im/py-matrix-synapse/files/patch-synapse_python__dependencies.py
@@ -1,11 +1,11 @@
---- synapse/python_dependencies.py.orig	2021-06-01 19:28:25 UTC
+--- synapse/python_dependencies.py.orig	2021-12-17 15:03:44 UTC
 +++ synapse/python_dependencies.py
-@@ -86,7 +86,7 @@ REQUIREMENTS = [
+@@ -85,7 +85,7 @@ REQUIREMENTS = [
      "typing-extensions>=3.7.4",
      # We enforce that we have a `cryptography` version that bundles an `openssl`
      # with the latest security patches.
 -    "cryptography>=3.4.7",
 +    "cryptography",
-     "ijson>=3.0",
+     "ijson>=3.1",
  ]