diff --git a/security/py-pycryptodome/Makefile b/security/py-pycryptodome/Makefile
index 7dc73dc403..e451ae2856 100644
--- a/security/py-pycryptodome/Makefile
+++ b/security/py-pycryptodome/Makefile
@@ -1,5 +1,5 @@
 PORTNAME=	pycryptodome
-DISTVERSION=	3.12.0
+DISTVERSION=	3.15.0
 CATEGORIES=	security python
 MASTER_SITES=	CHEESESHOP
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
@@ -11,8 +11,10 @@ LICENSE=	PD BSD2CLAUSE APACHE20
 LICENSE_COMB=	multi
 LICENSE_FILE=	${WRKSRC}/LICENSE.rst
 
+TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pycryptodome-test-vectors>=0:security/py-pycryptodome-test-vectors@${PY_FLAVOR}
+
 # Officially: 2.7, 3.5-3.10
-USES=		cpe python:3.6+ zip
+USES=		cpe python:3.7+
 CPE_VENDOR=	python
 USE_PYTHON=	autoplist distutils
 
@@ -29,6 +31,6 @@ post-install:
 	@${STRIP_CMD} ${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}/${NAMESPACE}/Util/*.so
 
 do-test:
-	@cd ${WRKSRC} && ${PYTHON_CMD} ${PYDISTUTILS_SETUP} test
+	@cd ${WRKSRC} && ${PYTHON_CMD} -m ${NAMESPACE}.SelfTest
 
 .include <bsd.port.mk>
diff --git a/security/py-pycryptodome/distinfo b/security/py-pycryptodome/distinfo
index 9eeb6e33fa..f335eebd14 100644
--- a/security/py-pycryptodome/distinfo
+++ b/security/py-pycryptodome/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1640650324
-SHA256 (pycryptodome-3.12.0.zip) = 12c7343aec5a3b3df5c47265281b12b611f26ec9367b6129199d67da54b768c1
-SIZE (pycryptodome-3.12.0.zip) = 3717073
+TIMESTAMP = 1657286387
+SHA256 (pycryptodome-3.15.0.tar.gz) = 9135dddad504592bcc18b0d2d95ce86c3a5ea87ec6447ef25cfedea12d6018b8
+SIZE (pycryptodome-3.15.0.tar.gz) = 4547210
diff --git a/security/py-pycryptodome/pkg-descr b/security/py-pycryptodome/pkg-descr
index 1ac395ac21..9658fb904c 100644
--- a/security/py-pycryptodome/pkg-descr
+++ b/security/py-pycryptodome/pkg-descr
@@ -5,10 +5,12 @@ PyCrypto (2.6.1):
 * Authenticated encryption modes (GCM, CCM, EAX, SIV, OCB)
 * Accelerated AES on Intel platforms via AES-NI
 * First class support for PyPy
+* Elliptic curves cryptography (NIST P-curves; Ed25519, Ed448)
+* Better and more compact API
 * SHA-3 (including SHAKE XOFs) and BLAKE2 hash algorithms
 * Salsa20 and ChaCha20 stream ciphers
 * scrypt and HKDF
-* Deterministic DSA
+* Deterministic (EC)DSA and EdDSA
 * Password-protected PKCS#8 key containers
 * Shamir's Secret Sharing scheme
 * Random numbers get sourced directly from the OS (and not from
@@ -17,4 +19,4 @@ PyCrypto (2.6.1):
 * Cleaner RSA and DSA key generation (largely based on FIPS 186-4)
 * Major clean ups and simplification of the code base
 
-WWW: https://www.pycryptodome.org/en/latest/
+WWW: https://www.pycryptodome.org/
diff --git a/security/py-pycryptodome/pkg-message b/security/py-pycryptodome/pkg-message
new file mode 100644
index 0000000000..b4bb2037fd
--- /dev/null
+++ b/security/py-pycryptodome/pkg-message
@@ -0,0 +1,10 @@
+[
+{   type: install
+    message: <<EOM
+Install the math/gmp port to enable accelerated processing with the GNU
+Multiple Precision Arithmetic Library. PyCryptodome will use the
+optional enhancement at runtime automatically if the library is
+available.
+EOM
+}
+]