diff --git a/science/orthanc/Makefile b/science/orthanc/Makefile
index 579ca9054910..a7424a3415cd 100644
--- a/science/orthanc/Makefile
+++ b/science/orthanc/Makefile
@@ -1,8 +1,9 @@
+# Created by: maintainer.freebsd@xpoundit.com
+
 PORTNAME=	orthanc
-DISTVERSION=	1.11.0
-PORTREVISION=	11
+DISTVERSION=	1.12.1
 CATEGORIES=	science
-MASTER_SITES=	https://www.orthanc-server.com/downloads/get.php?path=/orthanc/
+MASTER_SITES=	https://orthanc.uclouvain.be/downloads/sources/orthanc/
 DISTNAME=	Orthanc-${PORTVERSION}
 
 MAINTAINER=	maintainer.freebsd@xpoundit.com
@@ -12,6 +13,8 @@ WWW=		https://www.orthanc-server.com/
 LICENSE=	GPLv3
 LICENSE_FILE=	${WRKSRC}/COPYING
 
+BUILD_DEPENDS=	protoc:devel/protobuf
+
 LIB_DEPENDS=	libboost_atomic.so:devel/boost-libs \
 		libcivetweb.so:www/civetweb \
 		libcurl.so:ftp/curl \
@@ -20,9 +23,10 @@ LIB_DEPENDS=	libboost_atomic.so:devel/boost-libs \
 		libicuuc.so:devel/icu \
 		libjsoncpp.so:devel/jsoncpp \
 		libpng16.so:graphics/png \
+		libprotobuf.so:devel/protobuf \
 		libpugixml.so:textproc/pugixml \
 		libtiff.so:graphics/tiff \
-		libuuid.so:misc/e2fsprogs-libuuid
+		libuuid.so:misc/e2fsprogs-libuuid \
 
 USES=		cmake gnome iconv jpeg lua python:build sqlite ssl
 USE_GNOME=	libxml2
diff --git a/science/orthanc/distinfo b/science/orthanc/distinfo
index f28286e4fad0..cb1283d66b9d 100644
--- a/science/orthanc/distinfo
+++ b/science/orthanc/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1652266484
-SHA256 (Orthanc-1.11.0.tar.gz) = 23949a70562487fd6e79d6f3f13c71a0fc90aa25e492fb3a99575fee0722c5af
-SIZE (Orthanc-1.11.0.tar.gz) = 1899829
+TIMESTAMP = 1701766389
+SHA256 (Orthanc-1.12.1.tar.gz) = 2e8bfe1f56a4cf9a281eb3975549122ee13f2f4057279d88bb0dd09b006e6189
+SIZE (Orthanc-1.12.1.tar.gz) = 1991159
diff --git a/science/orthanc/files/patch-OrthancFramework_Resources_CMake_ProtobufConfiguration.cmake b/science/orthanc/files/patch-OrthancFramework_Resources_CMake_ProtobufConfiguration.cmake
new file mode 100644
index 000000000000..e6d9c8ff88cf
--- /dev/null
+++ b/science/orthanc/files/patch-OrthancFramework_Resources_CMake_ProtobufConfiguration.cmake
@@ -0,0 +1,37 @@
+--- OrthancFramework/Resources/CMake/ProtobufConfiguration.cmake.orig	2023-12-05 11:17:50 UTC
++++ OrthancFramework/Resources/CMake/ProtobufConfiguration.cmake
+@@ -64,22 +64,26 @@ else()
+     message(FATAL_ERROR "Please install the libprotobuf-dev package")
+   endif()
+ 
+-  set(CMAKE_REQUIRED_LIBRARIES "protobuf")
++  if (${CMAKE_SYSTEM_NAME} STREQUAL "FreeBSD")
++    find_package(Protobuf REQUIRED)
++  else()
++    set(CMAKE_REQUIRED_LIBRARIES "protobuf")
+ 
+-  include(CheckCXXSourceCompiles) 
+-  check_cxx_source_compiles(
+-    "
++    include(CheckCXXSourceCompiles) 
++    check_cxx_source_compiles(
++      "
+ #include <google/protobuf/descriptor.h>
+ int main()
+ {
+   google::protobuf::FieldDescriptor::TypeName(google::protobuf::FieldDescriptor::TYPE_FLOAT);
+ }
+ "  HAVE_PROTOBUF_LIB)
+-  if (NOT HAVE_PROTOBUF_LIB)
+-    message(FATAL_ERROR "Cannot find the protobuf library")
++    if (NOT HAVE_PROTOBUF_LIB)
++      message(FATAL_ERROR "Cannot find the protobuf library")
++    endif()
++
++    unset(CMAKE_REQUIRED_LIBRARIES)
+   endif()
+-  
+-  unset(CMAKE_REQUIRED_LIBRARIES)
+ 
+   link_libraries(protobuf)
+ endif()